Many concepts in biology are complex and very abstract involving processes that occur at the cellular and molecular levels. Using Edusmart Science Texas Biology, a TEKS-based online multimedia resource, computer simulated models and targeted hands on activities, we will explore how to build conceptual understanding of complex and very abstract concepts in biology whether used for primary instruction, End of Course Exam preparation, remediation or as part of a credit recovery program. The strategies and activities presented can be used with any resource.